FORMULATION AND EVALUATION OF PIOGLITAZONE SUSTAINED RELEASE TABLET

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. The matrix tablets were prepared by wet granulation method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Four formulations of different polymer percentages were formulated, (F1-F4).The formulated tablets were characterized by hardness, friability, thickness, weight variation and in vitro drug release. The formulated tablets had acceptable physicochemical characters. The quantity of pioglitazone present in the tablets and the release medium were estimated by a simple, rapid and validated UV method. The dissolution results show that increased amount of polymer resulted in reduced and extended drug release. This formulation may provide an alternative for oral controlled delivery of pioglitazone and be helpful in the future treatment of primary normoreactive types of inflammation. Keywords: Ibuprofen, HPMC, Wet granulation method, Dissolutio