The work presented is aimed at the investigation of the influence of beam-to-column connection typologies on the seismic response of regular and irregular MR-Frames designed according to the Theory of Plastic Mechanism Control (TPMC). The investigated typologies are four partial strength connections whose structural detail has been designed in order to obtain the same flexural resistance. The first three joints are designed by means of hierarchy criteria based on the component approach and are characterized by different location of the weakest joint component, leading to different values of joint rotational stiffness and plastic rotation supply and affecting the shape of the hysteresis loops governing the dissipative capacity. The last typo...