In an era of knowledge-based competition, technology transfer from university to firms is a key issue for the wealth of Nations and Regions. The creation of academic spin-off companies is one of the ways through which pursue such technology transfer process (TTP). Even if in Italy this form of TTP has become more and more popular in the last years (Netval, 2008), the gap with other EU countries remains large. In our opinion, the main problem lies in the lack of young researchers’ entrepreneurial commitment (Mises, 1949; Baumol, 1990) here understood as a complex of decisions and actions which bind the would be entrepreneur to the fate of his venture. In the first step of new venture creation, entrepreneurial commitment is a necessary ingred...