Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/insulin pathway in skeletal muscle, a key metabolic tissue. We also demonstrate that CR induces dramatic changes of the skeletal muscle transcriptional profile that resemble those of younger individuals. Finally, in both rats and humans, CR evoked similar responses in the transcriptional profiles of skeletal muscle. This common signature consisted of three key pathways typically associated with longevity: IGF-1/insulin signaling, mitochondrial bio...
Rodent skeletal muscle mitochondrial DNA has been shown to be a potential site of oxidative damage d...
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic...
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic...
Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interven...
Summary Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust ...
Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interven...
Calorie restriction (CR), reducing caloric intake without malnutrition, increases lifespan and delay...
Aging is the most significant risk factor for a range of diseases, including many cancers, neurodege...
<div><p>Aging is the most significant risk factor for a range of diseases, including many cancers, n...
[[abstract]]Caloric restriction (CR) attenuates age-related muscle loss. However, the underlying mec...
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In y...
In this study, we analyzed the effects of long-term (14 months) caloric restriction (CR) on the firs...
Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory proce...
Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a ...
SummaryCalorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum ...
Rodent skeletal muscle mitochondrial DNA has been shown to be a potential site of oxidative damage d...
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic...
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic...
Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interven...
Summary Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust ...
Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interven...
Calorie restriction (CR), reducing caloric intake without malnutrition, increases lifespan and delay...
Aging is the most significant risk factor for a range of diseases, including many cancers, neurodege...
<div><p>Aging is the most significant risk factor for a range of diseases, including many cancers, n...
[[abstract]]Caloric restriction (CR) attenuates age-related muscle loss. However, the underlying mec...
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In y...
In this study, we analyzed the effects of long-term (14 months) caloric restriction (CR) on the firs...
Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory proce...
Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a ...
SummaryCalorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum ...
Rodent skeletal muscle mitochondrial DNA has been shown to be a potential site of oxidative damage d...
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic...
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic...