Topics
agonistChemical compound
receptorProtein
NMRDisease
heterotrimeric G proteinBiomolecule
John Wiley & SonsCompany
dynamicsMusic genre
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activation of G proteins by their cognate receptors. Several C-terminal fragments of Gαs (from 11 to 21 residues) were recently synthesized. The ability of these peptides to stimulate agonist binding was found to be related to their size. Gαs(380-394) is a 15-mer peptide of intermediate length among those synthesized and tested that displays a biological activity surprisingly weak compared with that of the corresponding 21-mer peptide, shown to be the most active. In the present investigation, Gαs(380-394) was subjected to a conformational NMR analysis in a fluorinated isotropic environment. An NMR structure, calculated on the basis of the data de...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G ...
The heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins, Gαβγ ) mediate the si...
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activ...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G ...
The heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins, Gαβγ ) mediate the si...
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein α-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activ...
The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activ...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of Gα...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G,...
It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G ...
The heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins, Gαβγ ) mediate the si...
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