Low-dose effects of ionizing radiations in in vitro and in vivo biological systems: A multi-scale approach study
- Antoccia, A.
- Argazzi, E.
- Balata, M.
- Bedogni, R.
- Berardinelli, F.
- Bisogni, G.
- Bono, M.
- Brunetti, A.
- Buttafava, A.
- Castellani, G.
- Centis, F.
- Cesarini, W.
- Cherubini, R.
- Cossu, A.
- Cugia, G.
- Dattena, M.
- De Nadal, V.
- Dondi, D.
- Esposito, A.
- Faucitano, A.
- Fiori, P. L.
- Fusco, E.
- Gerardi, S.
- Laubenstein, M.
- Lucarini, A.
- Marengo, M.
- Masala, G. L.
- Nieri, D.
- Nisi, S.
- Picardi, F.
- Pintus, G.
- Posadino, A.
- Randaccio, P.
- Remondini, D
- Sgura, A.
- Stramigioli, S.
- Tanzarella, C.
- Valentini, M.
- Zamai, L.
- Zini, G.
- Zironi, I.
- BOTTIGLI, UBALDO
DOIAbstract
Long-term biological effects of low-dose radiation are little known nowadays and its carcinogenic risk is estimated on the assumption that the risk remains linearly proportional to the radiation dose down to low-dose levels. However in the last 20 years this hypothesis has gradually begun to seem in contrast with a huge collection of experimental evidences, which has shown the presence of a plethora of non-linear phenomena (including hypersensitivity and induced radioresistance, adaptive response, and non-targeted phenomena like bystander effect and genomic instability) occurring after low-dose irradiation. These phenomena might imply a non-linear behaviour of cancer risk curves in the low-dose region and question the validity of the Linear...
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