We argue that seismotectonic activity in the Central Mediterranean area and the Aegean-Balkan zone is driven by the NNE-ward motion of Africa and westward motion of Anatolia with respect to Eurasia. These boundary conditions can plausibly and coherently account for E-W shortening and roughly S-N extension in the Aegean domain, thrusting and uplift at the boundary between the Aegean-Balkan system and the Adriatic/Ionian domain (Hellenic trench, Cephalonia fault, Epirus, Albanides and Southern Dinarides), the kinematics of the Adria plate (a large block encompassing the Adriatic continental domain, the northern Ionian zone and Hyblean-Adventure block) and consequently, the complex pattern of deformation recognized at its boundaries. Furthermo...