Docking simulations were used to predict the most favorable interaction between the T315I mutated form of Abl (invariably associated with resistance to the tyrosine kinase inhibitor imatinib mesylate, IM) and C6-unsubstituted and substituted pyrazolo[3,4-d]pyrimidines previously found to be dual Src/Abl inhibitors. Two C6-unsubstituted (1 and 2) and eight C6-substituted compounds (3-10) were selected and assayed for their effects on the Ba/F3 cell line transducing the wild-type p210Bcr-Abl construct, which is IM-sensitive, or three of the most common mutations associated with IM resistance in vivo (T315I, Y253F, and E255K), and driven to drug resistance by saturating doses of IL-3 or by the expression of the Bcr-Abl construct coding for the...
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-ba...
The major clinical challenge in drug-resistant chronic myelogenous leukemia (CML) is currently repre...
The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cel...
Docking simulations were used to predict the most favorable interaction between the T315I mutated fo...
Docking simulations were used to predict the most favorable interaction between the T315I mutated fo...
Docking simulations were used to predict the most favorable interaction between the T3151 mutated fo...
A new class of compds. C6-unsubstituted [3,4d]pyrimidines with a remarkable inhibitory activity on e...
A series of pyrazolo[3,4-d]pyrimidines, previously found to be Src inhibitors, was tested for their ...
A series of pyrazolo[3,4-d]pyrimidines, previously found to be Src inhibitors, was tested for their ...
none7noneSantucci MA; Corradi V; Mancini M; Manetti F; Radi M; Schenone S; Botta M.Santucci MA; Corr...
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffol...
Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, a cross-docking simulation was con...
Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, a cross-docking simulation was con...
Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, a cross-docking simulation was con...
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffol...
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-ba...
The major clinical challenge in drug-resistant chronic myelogenous leukemia (CML) is currently repre...
The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cel...
Docking simulations were used to predict the most favorable interaction between the T315I mutated fo...
Docking simulations were used to predict the most favorable interaction between the T315I mutated fo...
Docking simulations were used to predict the most favorable interaction between the T3151 mutated fo...
A new class of compds. C6-unsubstituted [3,4d]pyrimidines with a remarkable inhibitory activity on e...
A series of pyrazolo[3,4-d]pyrimidines, previously found to be Src inhibitors, was tested for their ...
A series of pyrazolo[3,4-d]pyrimidines, previously found to be Src inhibitors, was tested for their ...
none7noneSantucci MA; Corradi V; Mancini M; Manetti F; Radi M; Schenone S; Botta M.Santucci MA; Corr...
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffol...
Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, a cross-docking simulation was con...
Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, a cross-docking simulation was con...
Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, a cross-docking simulation was con...
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffol...
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-ba...
The major clinical challenge in drug-resistant chronic myelogenous leukemia (CML) is currently repre...
The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cel...