Early postnatal perfusion index changes in term newborns with subclinical chorioamnionitis.

Background: Chorioamnionitis (HCA) in term newborns is often subclinical and associated with neonatal morbidity and mortality. Objective: To assess the value of the pulse oximetry perfusion index (PI) in the early prediction of subclinical HCA in term newborns. Methods: PI cut-off values were first identified in 51 term newborns with HCA and 115 matched controls, retrospectively categorised on the basis of placental histology (study phase 1). The PI thresholds obtained were subsequently tested on an unselected case series of 329 prospectively recruited, term newborns (study phase 2). PI was evaluated during the first five minutes after delivery. Initial illness severity and short term clinical outcomes were determined. Results: In study phase 1, newborns with HCA had lower PI one and five minutes (p<0.0001) after delivery, lower one minute Apgar score (p = 0.017), lower cord blood base excess (p = 0.0001), together with higher rates of admission to neonatal intensive care unit (p = 0.0001) and endotracheal intubation (p = 0.017), and higher SNAP-PE (p<0.0001) and NTISS (p