Bone adapts its architecture to the applied load; however, it is still unclear how bone mechano-adaptation is coordinated and why potential for adaptation adjusts during the life course. Previous animal models have suggested strain as the mechanical stimulus for bone adaptation, but yet it is unknown how mouse cortical bone load-related strains vary with age and sex. In this study, full-field strain maps (at 1 N increments up to 12 N) on the bone surface were measured in young, adult, and old (aged 10, 22 weeks, and 20 months, respectively), male and female C57BL/6J mice with load applied using a noninvasive murine tibial model. Strain maps indicate a nonuniform strain field across the tibial surface, with axial compressive loads resulting ...
IntroductionMechanical loading (i.e., exercise) is well known to influence bone mass [1]. Experiment...
The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal region...
The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal region...
Bone adapts its architecture to the applied load; however, it is still unclear how bone mechano-adap...
ABSTRACT Bone adapts its architecture to the applied load; however, it is still unclear how bone mec...
Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading b...
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in...
Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading b...
Bone ensures it is sufficiently robust to withstand habitual levels of mechanical loading without un...
Strain-induced adaption of bone has been well-studied in an axial loading model of the mouse tibia. ...
The in vivo mouse tibial loading model is used to evaluate the effectiveness of mechanical loading t...
Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading b...
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in...
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in...
The ability of the skeleton to adapt to mechanical stimuli diminishes with age in diaphyseal cortica...
IntroductionMechanical loading (i.e., exercise) is well known to influence bone mass [1]. Experiment...
The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal region...
The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal region...
Bone adapts its architecture to the applied load; however, it is still unclear how bone mechano-adap...
ABSTRACT Bone adapts its architecture to the applied load; however, it is still unclear how bone mec...
Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading b...
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in...
Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading b...
Bone ensures it is sufficiently robust to withstand habitual levels of mechanical loading without un...
Strain-induced adaption of bone has been well-studied in an axial loading model of the mouse tibia. ...
The in vivo mouse tibial loading model is used to evaluate the effectiveness of mechanical loading t...
Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading b...
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in...
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in...
The ability of the skeleton to adapt to mechanical stimuli diminishes with age in diaphyseal cortica...
IntroductionMechanical loading (i.e., exercise) is well known to influence bone mass [1]. Experiment...
The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal region...
The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal region...