Neutrophils are the first barrier against infections. Aged neutrophils display impaired oxidative burst and phagocytosis with subsequent less capability to destroy bacteria. In successful ageing (nonagenarians), neutrophil efficiency (phagocytosis) increases. After ingested microbes, aged neutrophils are less prone to undergo apoptosis favouring chronic inflammation. Moreover, the superoxide dismutase (SOD) activity, which is necessary in avoiding ROS produced by oxidative burst, is limited in ageing. The mechanisms of age-related changes in neutrophil function are not fully understood, taking also into account that nonagenarians escape infections in comparison with elderly. Zinc pool may be involved because it is pivotal for neutrophil eff...
Zinc supplementation can stimulate polymorphonuclear leukocyte (PMN) functions (phagocytosis and int...
Presentation entitled: The Effect of Intracellular Zinc Concentration on Immune Activation and Proin...
Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptib...
Neutrophils are the first barrier against infections. Aged neutrophils display impaired oxidative bu...
Life-long antigenic burden determines a condition of chronic inflammation, with increased lymphocyte...
Lifelong antigenic burden determines a condition of chronic inflammation, with increased lymphocyte ...
International audienceThe aim of our study was to analyze polymorphonuclear neutrophil (PMN) functio...
A hallmark of cellular ageing is the increase in the oxidatively modified proteins. Oxidative damage...
Objective: To evaluate neutrophil functions in the elderly. Methods: We investigated the PMN migrati...
Much attention has been drawn to the pro-inflammatory condition that accompanies aging. This study c...
Abstract: Neutrophil phagocytosis, reactive oxy-gen intermediate production (intra- and extracellu-l...
Aging is associated with a progressive decline of the immune system function, that ultimately result...
Blood polymorphonuclear neutrophils provide immune protection against pathogens, but may also promot...
Zinc supplementation can stimulate polymorphonuclear leukocyte (PMN) functions (phagocytosis and int...
Objective: To determine zinc status and age-related changes in the immune function of healthy late-m...
Zinc supplementation can stimulate polymorphonuclear leukocyte (PMN) functions (phagocytosis and int...
Presentation entitled: The Effect of Intracellular Zinc Concentration on Immune Activation and Proin...
Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptib...
Neutrophils are the first barrier against infections. Aged neutrophils display impaired oxidative bu...
Life-long antigenic burden determines a condition of chronic inflammation, with increased lymphocyte...
Lifelong antigenic burden determines a condition of chronic inflammation, with increased lymphocyte ...
International audienceThe aim of our study was to analyze polymorphonuclear neutrophil (PMN) functio...
A hallmark of cellular ageing is the increase in the oxidatively modified proteins. Oxidative damage...
Objective: To evaluate neutrophil functions in the elderly. Methods: We investigated the PMN migrati...
Much attention has been drawn to the pro-inflammatory condition that accompanies aging. This study c...
Abstract: Neutrophil phagocytosis, reactive oxy-gen intermediate production (intra- and extracellu-l...
Aging is associated with a progressive decline of the immune system function, that ultimately result...
Blood polymorphonuclear neutrophils provide immune protection against pathogens, but may also promot...
Zinc supplementation can stimulate polymorphonuclear leukocyte (PMN) functions (phagocytosis and int...
Objective: To determine zinc status and age-related changes in the immune function of healthy late-m...
Zinc supplementation can stimulate polymorphonuclear leukocyte (PMN) functions (phagocytosis and int...
Presentation entitled: The Effect of Intracellular Zinc Concentration on Immune Activation and Proin...
Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptib...