Development and validation of a prediction rule for growth hormone deficiency without need for pharmacological stimulation tests in children with risk factors
- Clément, Florencia
- Grinspon, Romina
- Yankelevich, Daniel Norberto
- Martín Benítez, Sabrina
- de la Ossa, Carolina
- Ropelato, Maria Gabriela
- Ballerini, Maria Gabriela
- Keselman, Ana Claudia
- Braslavsky, Debora Giselle
- Pennisi, Patricia Alejandra
- Bergadá, Ignacio
- Finkielstain, Gabriela Paula
- Rey, Rodolfo Alberto
DOIAbstract
Introduction: Practice guidelines cannot recommend establishing a diagnosis of growth hormone deficiency (GHD) without performing growth hormone stimulation tests (GHST) in children with risk factors, due to the lack of sufficient evidence. Objective: Our goal was to generate an evidence-based prediction rule to diagnose GHD in children with growth failure and clinically identifiable risk factors. Methods: We studied a cohort of children with growth failure to build the prediction model, and a second, independent cohort to validate the prediction rule. To this end, we assessed the existence of: pituitary dysgenesis, midline abnormalities, (supra)sellar tumor/surgery, CNS infection, traumatic brain injury, cranial radiotherapy, chemotherapy,...
Add to ORKG