Diagnosis of male central hypogonadism during childhood
- Grinspon, Romina
- Castro, Sebastián
- Brunello, Franco Gino
- Sanso, Elsa Gabriela
- Ropelato, Maria Gabriela
- Rey, Rodolfo Alberto
DOIAbstract
The diagnosis of male central (or hypogonadotropic) hypogonadism, typically based on low luteinizing hormone (LH) and testosterone levels, is challenging during childhood since both hormones are physiologically low from the sixth month until the onset of puberty. Conversely, follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH), which show higher circulating levels during infancy and childhood, are not used as biomarkers for the condition. We report the case of a 7-year-old boy with a history of bilateral cryptorchidism who showed repeatedly low FSH and AMH serum levels during prepuberty. Unfortunately, the diagnosis could not be ascertained until he presented with delayed puberty at the age of 14 years. A gonadotropin-releasi...
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