Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

A strategy of highly stereoselective enolate trapping of lithium (1S,2R,4R)- 10-dicyclohexylsulfamoylisobornyl-2-cyano-3,3-diphenylpropanoate combined with the appropriate rearrangement process allows the asymmetric synthesis of a novel a-methyl amino acid derived from 3,3diienylalanine (Dip).This work was supported by the Direccion General de Investigacion Cientifica y Tecnica, project number P691-0696.Peer reviewe