A new approach to the asymmetric synthesis of α-methyltryptophan

α-Methyltryptophan can easily be obtained in enantiomerically pure form through diastereoselective alkylation of a chiral 2-cyanopropanoate followed by the Curtius rearrangement. Non-proteinogenic, unnatural α-amino acids have attracted the attention of numerous researchers due to the widespread use of these compounds in physical and life science. Many synthetic methodologies have already been developed to obtain a wide range of optically active α-amino acids.Peer reviewe