Dose-response plot of the baseline HbA1c and adjusted hazard ratios for (A) progression to end-stage kidney disease and (B) all-cause mortality according to baseline HbA1c (%). Solid lines represent adjusted hazard ratios based on restricted cubic splines for baseline HbA1c, with knots at the 10th, 50th, and 90th percentiles. Shaded areas represent the upper and lower 95% confidence intervals. The reference was set at the 10th percentile of HbA1c levels. Variables adjusted are the same as that shown in Model 3 presented in Table 2. Missing values were imputed by multiple imputation.</p
<p>Hazard ratios for low (left) or high (middle) plasma betaine concentrations, and for high plasma ...
<p>Hazard ratios for all-cause mortality depending on kidney function were modeled by separate restr...
Hazard ratios, calibration and goodness of fit for models for end stage renal failure.</p
Hazard ratios (95% confidence interval) of progression to end-stage kidney disease (ESKD) and all-ca...
Plot of adjusted hazard ratio and 95% confidence intervals (as indicated by the curvilinear dash lin...
<p>r = −0.9043; Adjusted R<sup>2</sup> = 0.7918 Δ HbA1c = −1.037×Δ Dose+2.074 Δ Dose = −0.964×Δ HbA1...
<p>Percentiles are shown as vertical dotted lines. Abbreviations: P = percentile.</p
<p>r = −0.8900; Adjusted R<sup>2</sup> = 0.7624 Δ HbA1c = −72.0845×Δ Dose/Weight+2.4449 Δ Dose = (−Δ...
<p>Shaded region represents the 95% confidence intervals. This model was expressed relative to the 5...
<p>Shaded region represents the 95% confidence intervals. This model was expressed relative to the 5...
<p>Hb, hemoglobin; HR, hazard ratio; CI, confidence interval</p><p>Multivariate analysis sequentiall...
<p>Multivariable-adjusted HRs and 95% CIs for the incidence of end-stage renal disease (ESRD) for ev...
<p>BMI = body-mass index. CKD4-5 = CKD stage 4 or 5. ESRD = end-stage renal disease. CI = confidence...
<p>Cox proportional hazards regression analyses were used to calculate hazard ratios relative to the...
<p>Plots of Baseline Quantitative HBsAg in those who remained HBsAg positive throughout followup and...
<p>Hazard ratios for low (left) or high (middle) plasma betaine concentrations, and for high plasma ...
<p>Hazard ratios for all-cause mortality depending on kidney function were modeled by separate restr...
Hazard ratios, calibration and goodness of fit for models for end stage renal failure.</p
Hazard ratios (95% confidence interval) of progression to end-stage kidney disease (ESKD) and all-ca...
Plot of adjusted hazard ratio and 95% confidence intervals (as indicated by the curvilinear dash lin...
<p>r = −0.9043; Adjusted R<sup>2</sup> = 0.7918 Δ HbA1c = −1.037×Δ Dose+2.074 Δ Dose = −0.964×Δ HbA1...
<p>Percentiles are shown as vertical dotted lines. Abbreviations: P = percentile.</p
<p>r = −0.8900; Adjusted R<sup>2</sup> = 0.7624 Δ HbA1c = −72.0845×Δ Dose/Weight+2.4449 Δ Dose = (−Δ...
<p>Shaded region represents the 95% confidence intervals. This model was expressed relative to the 5...
<p>Shaded region represents the 95% confidence intervals. This model was expressed relative to the 5...
<p>Hb, hemoglobin; HR, hazard ratio; CI, confidence interval</p><p>Multivariate analysis sequentiall...
<p>Multivariable-adjusted HRs and 95% CIs for the incidence of end-stage renal disease (ESRD) for ev...
<p>BMI = body-mass index. CKD4-5 = CKD stage 4 or 5. ESRD = end-stage renal disease. CI = confidence...
<p>Cox proportional hazards regression analyses were used to calculate hazard ratios relative to the...
<p>Plots of Baseline Quantitative HBsAg in those who remained HBsAg positive throughout followup and...
<p>Hazard ratios for low (left) or high (middle) plasma betaine concentrations, and for high plasma ...
<p>Hazard ratios for all-cause mortality depending on kidney function were modeled by separate restr...
Hazard ratios, calibration and goodness of fit for models for end stage renal failure.</p