Adjusted hazard ratios (solid line) for all-cause mortality according to baseline concentrations of gamma gap from a restricted cubic spline model.

<p>Shaded region represents the 95% confidence intervals. This model was expressed relative to the 50^th percentile of the gamma gap with three knots placed according to Harrell’s percentiles. This model was adjusted for age, sex, race, estimated glomerular filtration rate, albuminuria, hypertension, smoking status, body mass index, total cholesterol, HDL-cholesterol, self-reported cancer, aspartate aminotransferase, alanine aminotransferase, total bilirubin, alkaline phosphatase, hepatitis B virus core Igg status, hepatitis C virus Igg status, C-reactive protein, white blood cell count, and serum albumin. The plot was truncated at the 0.5^th and 99.5^th percentiles of the gamma gap. The hazard ratios are shown on a natural log scale. This Fig is overlaid with a kernel density plot, showing the overall distribution of the baseline gamma gap. A vertical gray line represents the median value.