Upon exposure to biological fluids, the fouling of nanomaterial surfaces results in non-specific capture of proteins, which is particularly important when in contact with blood for in vivo and ex vivo applications. It is crucial to evaluate not just the protein components but also the glycans attached to those proteins. Polymer-tethered glycosylated gold nanoparticles have shown promise for use in biosensing/diagnostics, but the impact of the glycoprotein corona has not been established. Here we investigate how polymer-tethered glycosylated gold nanoparticles interact with serum proteins and demonstrate that the protein corona introduces new glycans and hence off-specific targeting capability. Using a panel of RAFT-derived polymers grafted ...
Biomolecular corona formation has emerged as a recurring and important phenomenon in nanomedicine th...
The use of nanoparticles (NPs) for biomedical applications implies their delivery into the organism ...
When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like proteins ...
Upon exposure to biological fluids, the fouling of nanomaterial surfaces results in non-specific cap...
Glycan–lectin interactions play essential roles in biology; as the site of attachment for pathogens,...
Hypothesis: Following blood administration, the pristine surface of nanoparticles (NPs) associates w...
Glycan–lectin interactions drive a diverse range of biological signaling and recognition processes. ...
Identifying and treating infectious diseases remains a challenge for modern healthcare professionals...
Glycan/lectin interactions drive a wide range of recognition and signal transduction processes withi...
The development of new analytical tools as point-of-care biosensors is crucial to combat the spread ...
Carbohydrates dictate many biological processes including infection by pathogens. Glycosylated polym...
The identification and treatment of bacterial infections remains a major healthcare challenge, espec...
Glycomaterials display enhanced binding affinity to carbohydrate-binding proteins due to the nonline...
The COVID-19 pandemic has highlighted the need for innovative biosensing, diagnostic, and surveillan...
Multivalent lectin-glycan interactions are widespread in biology and are often exploited by pathogen...
Biomolecular corona formation has emerged as a recurring and important phenomenon in nanomedicine th...
The use of nanoparticles (NPs) for biomedical applications implies their delivery into the organism ...
When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like proteins ...
Upon exposure to biological fluids, the fouling of nanomaterial surfaces results in non-specific cap...
Glycan–lectin interactions play essential roles in biology; as the site of attachment for pathogens,...
Hypothesis: Following blood administration, the pristine surface of nanoparticles (NPs) associates w...
Glycan–lectin interactions drive a diverse range of biological signaling and recognition processes. ...
Identifying and treating infectious diseases remains a challenge for modern healthcare professionals...
Glycan/lectin interactions drive a wide range of recognition and signal transduction processes withi...
The development of new analytical tools as point-of-care biosensors is crucial to combat the spread ...
Carbohydrates dictate many biological processes including infection by pathogens. Glycosylated polym...
The identification and treatment of bacterial infections remains a major healthcare challenge, espec...
Glycomaterials display enhanced binding affinity to carbohydrate-binding proteins due to the nonline...
The COVID-19 pandemic has highlighted the need for innovative biosensing, diagnostic, and surveillan...
Multivalent lectin-glycan interactions are widespread in biology and are often exploited by pathogen...
Biomolecular corona formation has emerged as a recurring and important phenomenon in nanomedicine th...
The use of nanoparticles (NPs) for biomedical applications implies their delivery into the organism ...
When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like proteins ...