Biomarker-assisted assessment of aquatic health using the cosmopolitan common carp, Cyprinus carpio. (L): a case study of bisphenol-A exposures

Monitoring aquatic health from environmental pollutants is critical, none more so than bisphenol-A (BPA), a ubiquitous endocrine-disrupting chemical (EDC). The present study brings out the responses of selected transcripts, hormone levels, and tissue histomorphology in a widely distributed fish species Cyprinus carpio (Linn.), following exposure to environmentally relevant (10, 100 ng/L) and higher (1000 ng/L) concentration of BPA. The response of cyp19a1a, cyp19a1b, and c3 significantly decreased, while that of vtg increased in their respective tissue domains. The hematological parameters TEC, Hb, and Hct decreased significantly in contrast to TLC (p 3, T4, and TSH) were suppressed significantly (p C. carpio should allow comparative studies of pollutants at environmental concentrations