Add to ORKGIn bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreover propagates through the cell and adds to fluctuations in the cellular growth rate. A common intuition is that, due to their relatively high noise amplitudes, proteins with a low mean expression level are the most important drivers of fluctuations in physiological variables. In this work, we challenge this intuition by considering the effect of natural selection on noise propagation. Mathematically, the contribution of each protein species to the noise in the growth rate depends on two factors: The noise amplitude of the protein's expression level, and the sensitivity of the growth rate to fluctuations in that protein's concentration. We argu...
During the last decades experimental studies have revealed that single cells of a growing bacterial ...
All organisms have elaborate mechanisms to control rates of protein production. However, protein pro...
<div><p>All organisms have elaborate mechanisms to control rates of protein production. However, pro...
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreove...
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreove...
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreove...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
At the single cell level, bacterial gene expression is a highly stochastic process. Protein concentr...
Protein expression in a single cell depends on its global physiological state. Moreover, genetically...
<div><p>During the last decades experimental studies have revealed that single cells of a growing ba...
During the last decades experimental studies have revealed that single cells of a growing bacterial ...
All organisms have elaborate mechanisms to control rates of protein production. However, protein pro...
<div><p>All organisms have elaborate mechanisms to control rates of protein production. However, pro...
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreove...
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreove...
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreove...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
In bacterial cells, gene expression, metabolism, and growth are highly interdependent and tightly co...
At the single cell level, bacterial gene expression is a highly stochastic process. Protein concentr...
Protein expression in a single cell depends on its global physiological state. Moreover, genetically...
<div><p>During the last decades experimental studies have revealed that single cells of a growing ba...
During the last decades experimental studies have revealed that single cells of a growing bacterial ...
All organisms have elaborate mechanisms to control rates of protein production. However, protein pro...
<div><p>All organisms have elaborate mechanisms to control rates of protein production. However, pro...