The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis (TB), is notoriously hard to diagnose. Here we show that integrating cerebrospinal fluid (CSF) metagenomic next-generation sequencing (mNGS) with a host gene expression-based machine learning classifier (MLC) enhances diagnostic accuracy for TB meningitis (TBM) and its mimics. 368 HIV-infected Ugandan adults with subacute meningitis were prospectively enrolled. Total RNA and DNA CSF mNGS libraries were sequenced to identify meningitis pathogens. In parallel, a CSF host transcriptomic MLC to distinguish between TBM and other infections was trained and then evaluated in a...
Over the past two decades, the diagnosis rate for patients with encephalitis has remained poor despi...
Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-performance d...
Background Meningoencephalitis is a devastating disease worldwide. Current diagnosis fails to establ...
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, an...
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, an...
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, an...
Importance:Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhan...
ABSTRACT Meningitis and encephalitis are leading causes of central nervous system (CNS) disease and ...
The burden of meningitis in low-and-middle-income countries remains significant, but the infectious ...
The burden of meningitis in low-and-middle-income countries remains significant, but the infectious ...
BackgroundMetagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potentia...
International audienceBackground: Point-Of-Care (POC) diagnosis of life-threatening community-acquir...
International audienceBackground: Point-Of-Care (POC) diagnosis of life-threatening community-acquir...
Globally, there are an estimated 10.6 million cases of meningitis and 288,000 deaths every year, wit...
Over the past two decades, the diagnosis rate for patients with encephalitis has remained poor despi...
Over the past two decades, the diagnosis rate for patients with encephalitis has remained poor despi...
Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-performance d...
Background Meningoencephalitis is a devastating disease worldwide. Current diagnosis fails to establ...
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, an...
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, an...
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, an...
Importance:Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhan...
ABSTRACT Meningitis and encephalitis are leading causes of central nervous system (CNS) disease and ...
The burden of meningitis in low-and-middle-income countries remains significant, but the infectious ...
The burden of meningitis in low-and-middle-income countries remains significant, but the infectious ...
BackgroundMetagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potentia...
International audienceBackground: Point-Of-Care (POC) diagnosis of life-threatening community-acquir...
International audienceBackground: Point-Of-Care (POC) diagnosis of life-threatening community-acquir...
Globally, there are an estimated 10.6 million cases of meningitis and 288,000 deaths every year, wit...
Over the past two decades, the diagnosis rate for patients with encephalitis has remained poor despi...
Over the past two decades, the diagnosis rate for patients with encephalitis has remained poor despi...
Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-performance d...
Background Meningoencephalitis is a devastating disease worldwide. Current diagnosis fails to establ...