Following the empirical observation of widespread collapses of cladding panel connections of precast industrial buildings under recent seismic events, new design solutions have been developed in the framework of the European project SAFECLADDING, including isostatic systems effectively decoupling the seismic response of frame structure and cladding panels. The present paper is aimed at evaluating the seismic response and vulnerability of precast frame structures employing pendulum, cantilever, and rocking cladding connection systems. Within the framework of the research project RINTC–Implicit seismic risk of code-conforming structures funded by the Italian Civil Protection Department within the ReLUIS program, the seismic performance of a t...