Michelangelo Buonarroti devoted the last years of his life to work on Pietà Rondanini. The statue reached Milano in the ‘50s and it became one of the most important pieces of the Castello Sforzesco collections. In view of Expo 2015, Ospedale Spagnolo was chosen as the new exposition space for the artwork. Subway lines under the new space was recognized as source of vibrations, not present to the same extent in the previous location. Since there is no consolidated knowledge about the effects of low and continuous vibrations on ancient marble, this type of excitation is discussed in this work, together with the peak vibration levels usually considered in scientific literature. In the case study of this work a conservative approach has be...