Climate change has repercussions on the management of water resources. Particularly, changes in precipitation and temperature impact hydropower generation and revenue by affecting seasonal electricity prices and streamflow. This issue exemplifies the impact of climate change on the water-energy-nexus, which has raised serious concern. This paper investigates the impact of climate change on hydropower with a multidisciplinary approach. A holistic perspective should be favored as the issue is complex, consequently, we chose to investigate a specific case study in Italy. It allows grasping the details, which matters in mountainous area. We integrated a hydrological model, hydropower management model, nine climate scenarios, and five electricit...