Wire-and-Arc Additive Manufacturing (WAAM) has been recently adopted to create innovative structural forms and architectural shapes. As shown by few experimental investigations, the layer-by-layer deposition induces a remarkable anisotropy in the elastic response of the WAAM-produced alloys. A suitable topology optimization technique is implemented to account for this peculiar behavior of the material, which is generally disregarded in design tools that are conceived for traditional manufacturing. First, an orthotropic material model is derived from the data of an experimental investigation that was recently performed on alloys made with 308LSi stainless steel wire feed. Then, an optimization procedure is implemented that exploits, as desig...