It has often been said that the knowability of substances became a problem in the early modern period, when anti-Aristotelians doubted that we could know anything more than the sensory qualities that are present to us. This article argues that the late scholastic Aristotelian Francisco Suárez was already aware of this sceptical problem. On his view, substances are really (and not just modally) distinct from the perceivable qualities, and therefore cannot be known through sense perception. The article first examines the metaphysical theory that motivated him to defend this thesis. It then looks at the epistemological consequences he drew from it. Though he rejected direct knowledge of substances, he nevertheless conceded that knowledge can b...