National audienceWe adapted an integrated model, RESPONSE, to assess the cost-optimized timing of oceanic, geological, and biological carbon sequestration versus fossil emission reduction to mitigate climate change in a context of uncertainty and learning about the magnitude of climate sensitivity to greenhouse-gas forcing. We find that the replacement of abatement measures in the energy sector by various sequestration measures can cut total mitigation policy costs by up to 35% for the Intergovernmental Panel on Climate Change (WMO and UNEP) A1B and A2 emissions scenarios. Biological carbon sequestration and carbon capture and geological or oceanic storage (CCS) contribute to relaxing carbon constraints on the energy sector while adapting t...