Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons
- David, François
- Crunelli, Vincenzo
- Leresche, Nathalie
- Lambert, Régis C
DOIAbstract
International audienceDuring non-REM sleep the EEG shows characteristics waves that are generated by the dynamic interactions between cortical and thalamic oscillators. In thalamic neurons, low-threshold T-type Ca 2+ channels play a pivotal role in almost every type of neuronal oscillations, including slow (<1 Hz) waves, sleep spindles and delta waves. The transient opening of T channels gives rise to the low threshold spikes (LTSs), and associated high frequency bursts of action potentials, that are characteristically present during sleep spindles and delta waves, whereas the persistent opening of a small fraction of T channels, (i.e., I Twindow) is responsible for the membrane potential bistability underlying sleep slow oscillations. Surp...
Add to ORKG