SECOND DEGREE BURN WOUND HEALING ACTIVITY TEST OF ETHANOL EXTRACT MAHOGANY BARK (SWIETENIA MAHAGONI (L.) JACQ.)

Objective: This research aims to determine the characteristics and activity of an ethanolic extract of mahogany bark on the healing rate of second-degree burns. Methods: The animal test consisted of 25 white male rats of the Sprague Dawley strain divided into five groups. The positive group was treated by Lanakeloid-E®cream, negative group, and treatment groups with varying dosages (100, 200, and 400 mg/Kg Bodyweight). The parameters observed included the time formed, the scab’s shedding time, and the percentage of wound healing. Burn area data were analyzed using the one-way ANOVA test to see if there were differences in the percentage of burns healing between groups. Results: The results showed that ethanol extract of mahogany bark (Swietenia mahagoni (L.) Jacq.) at a dose of 400 mg/Kg Bodyweightwas the best dose for accelerating burn healing with a recovery rate of 85,706% during 14 d. Statistical test results on the percentage of burn injury between negative and positive controls and the test groups had significantly different results (p<0,05). Conclusion: This study concludes that presenting the ethanol extract of mahogany bark (Swietenia mahagoni (L.) Jacq) at a dose of 400 mg/Kg Bodyweight shows the best second-degree burns healing