Air conditioning is needed to maintain thermal comfort which can be applied in hospital buildings. The isolation room in the hospital requires special treatment on its air conditioning, namely by controlling the room pressure to prevent the spread of bacteria and viruses outside the room, therefore it is necessary to design a good and correct air conditioning system by paying attention to the load of the room cooling, conditioning equipment, the right equipment, and psychometric analysis according to standards applicable for isolation rooms. The air conditioning system used uses AHU water chilled, where cold water from the chiller will cool the air that enters the AHU and then the cold air produced will be distributed to the isolation room ...