Cardiology News / Recent Literature Review / Last Quarter 2021: Cardiology News

Recent Cardiology Literature Review (Rhythmos 2022;17(1):107-114. ) Cardiology Meetings: 27th Annual International AF Symposium, 13-15/1/22, New York, NY, USA ACC.22, Washington, DC, USA, 2-4/4/22 EHRA 22, Copenhagen, Denmark, 3-5/4/22 HRS 22, San Francisco, CA, USA, 29/4-1/5/22 EuroPCR, Paris, France, 17-20/5/22 ESC Meeting, Barcelona, Spain, 26-29/8/2022 TCT 22, Boston, MA, USA, 16-20/9/22 Brugada Syndrome (BrS) is Associated With Increased Collagen Content Throughout Both Ventricles, With Maximal Collagen Proportions Observed Within BrS RVOT Epicardium Evaluation of 28 whole hearts from consecutive sudden cardiac death cases attributed to BrS (75% men; median age of death 25 years, death occurred in sleep or at rest in 86%) and 29 hearts from a comparator group comprised of noncardiac deaths (control subjects), showed that the highest proportion of collagen was observed in the epicardial right ventricular outflow tract (RVOT) of the BrS group (23.7%). Ventricular myocardium from BrS decedents demonstrated a higher proportion of collagen compared with controls (ratio 1.45; P<0.001), with no significant interactions with respect to sampling location or tissue layer. There was insufficient evidence to support differences in collagen proportion in SCN5A-positive cases (n=5) vs control subjects (ratio 1.23; P=0.27) (Miles C et al, J Am Coll Cardiol 2021;78:1511–21). XIENCE Short DAPT Program: Among High Bleeding Risk (HBR) Patients Undergoing PCI, 1-Month DAPT, Compared With 3-Month DAPT, Was Associated With Similar Ischemic Outcomes and Lower Bleeding Risk Patients who received 1-month DAPT (XIENCE 28 USA and 28 Global; n=1392) were compared with those on 3-month DAPT (XIENCE 90; n= 1972) using propensity score stratification. The primary endpoint of all-cause mortality or myocardial infarction was similar between the 2 groups (7.3% vs 7.5%; P=0.41). The key secondary endpoint of BARC (Bleeding Academic Research Consortium) type 2-5 bleeding was lower with 1-month DAPT compared with 3-month DAPT (7.6% vs 10%; P=0.012). Major BARC type 3-5 bleeding did not differ at 12 months (3.6% vs 4.7%; P=0.082), but was lower with 1-month DAPT at 90 days (1.0% vs 2.1%; P=0.015) (Valgimigli M et al, J Am Coll Cardiol 2021;78:2060–2072). A Booster (Third Dose) at Least 5 Months After a Second Dose of BNT162b2 Vaccine (Pfizer–BioNTech) Conferred 90% Lower Mortality Due to Covid-19 vs Those Who Did Not Receive a Booster Among 843,208 participants 758,118 (90%) received the booster during the 54-day study period. Death due to Covid-19 occurred in 65 participants in the booster group (0.16 per 100,000 persons per day) and in 137 participants in the nonbooster group (2.98 per 100,000 persons per day). The adjusted hazard ratio–HR for death due to Covid-19 in the booster group, as compared with the nonbooster group, was 0.10 (P<0.001) (Arbel R et al, N Engl J Med 2021; 385:2413-2420)... (excerpt