An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides

Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB

Nicole Hauser (1822798)
Kendra A. Ireland (14301120)
Vasiliki T. Chioti (16496186)
Clarissa C. Forneris (4786527)
Katherine M. Davis (2135110)
Mohammad R. Seyedsayamdost (129142)

July 2023

The emergence of multidrug-resistant pathogens poses a threat to public health and requires new anti...

Homologs of the vancomycin resistance d-Ala-d-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function

Lessard, Ivan A.D.
Pratt, Steve D.
McCafferty, Dewey G.
Bussiere, Dirksen E.
Hutchins, Charles
Wanner, Barry L.
Katz, Leonard
Walsh, Christopher T.

September 1998

AbstractBackground: Vancomycin-resistant enterococci are pathogenic bacteria that have altered cell-...

Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727

Binda E.
MARCONE, GIORGIA LETIZIA
POLLEGIONI, LOREDANO
MARINELLI, FLAVIA

January 2012

VanY(n) is a novel protein involved in the mechanism of self-resistance in Nonomuraea sp. ATCC 39727...

Synthesis of peptidoglycan peptides for DNA aptamer selection

Zhang, Wenxuan

January 2018

Gram-positive bacteria possess a thick layer of peptidoglycan outside the cell membrane that is rigi...

Vancomycin resistance in enterococci: reprogramming of the d-Ala–d-Ala ligases in bacterial peptidoglycan biosynthesis

Healy, Vicki L
Lessard, Ivan AD
Roper, David I
Knox, James R
Walsh, Christopher T

May 2000

AbstractVancomycin binds to bacterial cell-wall intermediates to achieve its antibiotic effect. Infe...

Incorporation of a valine−leucine−lysine-containing substrate in the bacterial cell wall

Hansenova Manaskova, S.
Bikker, F.J.
Nazmi, K.
van Zuidam, R.
Slotman, J.A.
van Capellen, W.A.
Houtsmuller, A.B.
Veerman, E.C.I.
Kaman, W.E.

January 2016

The emergence of antibiotic-resistant bacteria is a major public health threat, and therefore novel ...

Substrate Inhibition of VanA by D-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner

Aart, L.T. van der
Lemmens, N.
Wamel, W.J. van
Wezel, G.P. van

August 2016

The increasing resistance of clinical pathogens against the glycopeptide antibiotic vancomycin, a la...

Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy.

Thayer, D. A.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity

Mesleh, Michael F.
Rajaratnam, Premraj
Conrad, Mary
Chandrasekaran, Vasu
Liu, Christopher M.
Pandya, Bhaumik A.
Hwang, You Seok
Rye, Peter T.
Muldoon, Craig
Becker, Bernd
Zuegg, Johannes
Meutermans, Wim
Moy, Terence I.

February 2016

Synthesis of bacterial cell wall peptidoglycan requires glycosyltransferase enzymes that transfer th...

Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries: J.Antimicrob.Chemother.

El Zoeiby, A.
Sanschagrin, F.
Darveau, A.
Brisson, J.
Levesque, R.

March 2003

OBJECTIVES: The machinery of peptidoglycan biosynthesis is an ideal site at which to look for novel ...

Iterative chemical engineering of vancomycin leads to novel vancomycin analogs with a high in vitro therapeutic index

Mishra N.M.
Stolarzewicz I.
Cannaerts D.
Schuermans J.
Lavigne R.
Looz Y.
Landuyt B.
Schoofs L.
Schols D.
Paeshuyse J.
Hickenbotham P.
Clokie M.
Luyten W.
Briers Y.
Van Der Eycken E.V.

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

DEVELOPING A BIOCATALYTIC TOOLBOX TO AID IN UNDERSTANDING NUCLEOSIDE ANTIBIOTICS

Woods, Jasmine Brianna

January 2023

Antibiotic resistance happens when bacteria develop the ability to survive medications that normally...

Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

Thayer, D.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

NM Mishra (7807733)
I Stolarzewicz (7807736)
D Cannaerts (7807739)
J Schuermans (7807742)
R Lavigne (7707797)
Y Looz (7807745)
B Landuyt (7807748)
L Schoofs (7807751)
D Schols (7807754)
J Paeshuyse (7807757)
P Hickenbotham (7807760)
M Clokie (7807763)
W Luyten (7807766)
EV Van der Eycken (7807769)
Y Briers (7807772)

June 2018

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

Synthesis of Functionalized N‑Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis

Kristen E. DeMeester (5541212)
Hai Liang (785046)
Matthew R. Jensen (3609626)
Zachary S. Jones (5541209)
Elizabeth A. D’Ambrosio (5541206)
Samuel L. Scinto (2627449)
Junhui Zhou (841759)
Catherine L. Grimes (2406814)

July 2018

Uridine diphosphate N-acetyl muramic acid (UDP NAM) is a critical intermediate in bacterial p...

Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB

Nicole Hauser (1822798)
Kendra A. Ireland (14301120)
Vasiliki T. Chioti (16496186)
Clarissa C. Forneris (4786527)
Katherine M. Davis (2135110)
Mohammad R. Seyedsayamdost (129142)

July 2023

The emergence of multidrug-resistant pathogens poses a threat to public health and requires new anti...

Homologs of the vancomycin resistance d-Ala-d-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function

Lessard, Ivan A.D.
Pratt, Steve D.
McCafferty, Dewey G.
Bussiere, Dirksen E.
Hutchins, Charles
Wanner, Barry L.
Katz, Leonard
Walsh, Christopher T.

September 1998

AbstractBackground: Vancomycin-resistant enterococci are pathogenic bacteria that have altered cell-...

Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727

Binda E.
MARCONE, GIORGIA LETIZIA
POLLEGIONI, LOREDANO
MARINELLI, FLAVIA

January 2012

VanY(n) is a novel protein involved in the mechanism of self-resistance in Nonomuraea sp. ATCC 39727...

Synthesis of peptidoglycan peptides for DNA aptamer selection

Zhang, Wenxuan

January 2018

Gram-positive bacteria possess a thick layer of peptidoglycan outside the cell membrane that is rigi...

Vancomycin resistance in enterococci: reprogramming of the d-Ala–d-Ala ligases in bacterial peptidoglycan biosynthesis

Healy, Vicki L
Lessard, Ivan AD
Roper, David I
Knox, James R
Walsh, Christopher T

May 2000

AbstractVancomycin binds to bacterial cell-wall intermediates to achieve its antibiotic effect. Infe...

Incorporation of a valine−leucine−lysine-containing substrate in the bacterial cell wall

Hansenova Manaskova, S.
Bikker, F.J.
Nazmi, K.
van Zuidam, R.
Slotman, J.A.
van Capellen, W.A.
Houtsmuller, A.B.
Veerman, E.C.I.
Kaman, W.E.

January 2016

The emergence of antibiotic-resistant bacteria is a major public health threat, and therefore novel ...

Substrate Inhibition of VanA by D-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner

Aart, L.T. van der
Lemmens, N.
Wamel, W.J. van
Wezel, G.P. van

August 2016

The increasing resistance of clinical pathogens against the glycopeptide antibiotic vancomycin, a la...

Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy.

Thayer, D. A.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity

Mesleh, Michael F.
Rajaratnam, Premraj
Conrad, Mary
Chandrasekaran, Vasu
Liu, Christopher M.
Pandya, Bhaumik A.
Hwang, You Seok
Rye, Peter T.
Muldoon, Craig
Becker, Bernd
Zuegg, Johannes
Meutermans, Wim
Moy, Terence I.

February 2016

Synthesis of bacterial cell wall peptidoglycan requires glycosyltransferase enzymes that transfer th...

Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries: J.Antimicrob.Chemother.

El Zoeiby, A.
Sanschagrin, F.
Darveau, A.
Brisson, J.
Levesque, R.

March 2003

OBJECTIVES: The machinery of peptidoglycan biosynthesis is an ideal site at which to look for novel ...

Iterative chemical engineering of vancomycin leads to novel vancomycin analogs with a high in vitro therapeutic index

Mishra N.M.
Stolarzewicz I.
Cannaerts D.
Schuermans J.
Lavigne R.
Looz Y.
Landuyt B.
Schoofs L.
Schols D.
Paeshuyse J.
Hickenbotham P.
Clokie M.
Luyten W.
Briers Y.
Van Der Eycken E.V.

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

DEVELOPING A BIOCATALYTIC TOOLBOX TO AID IN UNDERSTANDING NUCLEOSIDE ANTIBIOTICS

Woods, Jasmine Brianna

January 2023

Antibiotic resistance happens when bacteria develop the ability to survive medications that normally...

Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

Thayer, D.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

NM Mishra (7807733)
I Stolarzewicz (7807736)
D Cannaerts (7807739)
J Schuermans (7807742)
R Lavigne (7707797)
Y Looz (7807745)
B Landuyt (7807748)
L Schoofs (7807751)
D Schols (7807754)
J Paeshuyse (7807757)
P Hickenbotham (7807760)
M Clokie (7807763)
W Luyten (7807766)
EV Van der Eycken (7807769)
Y Briers (7807772)

June 2018

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

Synthesis of Functionalized N‑Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis

Kristen E. DeMeester (5541212)
Hai Liang (785046)
Matthew R. Jensen (3609626)
Zachary S. Jones (5541209)
Elizabeth A. D’Ambrosio (5541206)
Samuel L. Scinto (2627449)
Junhui Zhou (841759)
Catherine L. Grimes (2406814)

July 2018

Uridine diphosphate N-acetyl muramic acid (UDP NAM) is a critical intermediate in bacterial p...

Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB

Nicole Hauser (1822798)
Kendra A. Ireland (14301120)
Vasiliki T. Chioti (16496186)
Clarissa C. Forneris (4786527)
Katherine M. Davis (2135110)
Mohammad R. Seyedsayamdost (129142)

July 2023

The emergence of multidrug-resistant pathogens poses a threat to public health and requires new anti...

Homologs of the vancomycin resistance d-Ala-d-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function

Lessard, Ivan A.D.
Pratt, Steve D.
McCafferty, Dewey G.
Bussiere, Dirksen E.
Hutchins, Charles
Wanner, Barry L.
Katz, Leonard
Walsh, Christopher T.

September 1998

AbstractBackground: Vancomycin-resistant enterococci are pathogenic bacteria that have altered cell-...

Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727

Binda E.
MARCONE, GIORGIA LETIZIA
POLLEGIONI, LOREDANO
MARINELLI, FLAVIA

January 2012

VanY(n) is a novel protein involved in the mechanism of self-resistance in Nonomuraea sp. ATCC 39727...

An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides

Abstract

Extracted data

An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides

Abstract

Extracted data

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