Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis

Sinha Roy, Ranabir
Yang, Ping
Kodali, Srinivas
Xiong, Yusheng
Kim, Ronald M
Griffin, Patrick R
Onishi, H.Russell
Kohler, Joyce
Silver, Lynn L
Chapman, Kevin

November 2001

AbstractBackground: The glycopeptide antibiotic vancomycin complexes DAla-DAla termini of bacterial ...

Impact of linker modification and PEGylation of vancomycin conjugates on structure-activity relationships and pharmacokinetics

Umstätter, Florian
Werner, Julia
Zerlin, Leah
Mühlberg, Eric
Kleist, Christian
Klika, Karel D.
Hertlein, Tobias
Beijer, Barbro
Domhan, Cornelius
Zimmermann, Stefan
Ohlsen, Knut
Haberkorn, Uwe
Mier, Walter
Uhl, Philipp

January 2022

As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dram...

Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides

Umstätter, Florian
Domhan, Cornelius
Hertlein, Tobias
Ohlsen, Knut
Mühlberg, Eric
Kleist, Christian
Zimmermann, Stefan
Beijer, Barbro
Klika, Karel D.
Haberkorn, Uwe
Mier, Walter
Uhl, Philipp

January 2020

Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The inc...

Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy.

Thayer, D. A.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: a case study of vancomycin

Ritter, T. K.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Iterative chemical engineering of vancomycin leads to novel vancomycin analogs with a high in vitro therapeutic index

Mishra N.M.
Stolarzewicz I.
Cannaerts D.
Schuermans J.
Lavigne R.
Looz Y.
Landuyt B.
Schoofs L.
Schols D.
Paeshuyse J.
Hickenbotham P.
Clokie M.
Luyten W.
Briers Y.
Van Der Eycken E.V.

March 2020

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

NM Mishra (7807733)
I Stolarzewicz (7807736)
D Cannaerts (7807739)
J Schuermans (7807742)
R Lavigne (7707797)
Y Looz (7807745)
B Landuyt (7807748)
L Schoofs (7807751)
D Schols (7807754)
J Paeshuyse (7807757)
P Hickenbotham (7807760)
M Clokie (7807763)
W Luyten (7807766)
EV Van der Eycken (7807769)
Y Briers (7807772)

June 2018

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

Dongliang Guan (4731594)
Feifei Chen (283821)
Lun Xiong (4731597)
Feng Tang (136667)
Faridoon (4731588)
Yunguang Qiu (4731591)
Naixia Zhang (474251)
Likun Gong (172599)
Jian Li (41607)
Lefu Lan (345536)
Wei Huang (36889)

December 2017

Lipophilic substitution on vancomycin is an effective strategy for the development of novel vancomyc...

Natural Product Disaccharide Engineering through Tandem Glycosyltransferase Catalysis Reversibility and Neoglycosylation

Pauline Peltier-Pain (1323909)
Karen Marchillo (1376943)
Maoquan Zhou (1906096)
David R. Andes (146260)
Jon S. Thorson (534543)

October 2012

A two-step strategy for disaccharide modulation using vancomycin as a model is reported. The strateg...

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

Nakayama, Atsushi
Okano, Akinori
Feng, Yiqing
Collins, James C.
Collins, Karen C.
Walsh, Christopher T.
Boger, Dale L.

August 2014

Studies on the further development of the sequential glycosylations of the vancomycin aglycon cataly...

Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides

Losey, Heather C.
Jiang, Jiqing
Biggins, John B.
Oberthür, Markus
Ye, Xiang-Yang
Dong, Steven D.
Kahne, Daniel
Thorson, Jon S.
Walsh, Christopher T.

December 2002

AbstractAnalogs of the glycopeptide antibiotics vancomycin and teicoplanin with alterations in one o...

Substrate Inhibition of VanA by D-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner

Aart, L.T. van der
Lemmens, N.
Wamel, W.J. van
Wezel, G.P. van

August 2016

The increasing resistance of clinical pathogens against the glycopeptide antibiotic vancomycin, a la...

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C‑Terminus Substituent Effects of the Aglycon Substrate

Christopher T. Walsh
Dale L. Boger

August 2016

ABSTRACT: Studies on the further development of the sequential glycosylations of the vancomycin agly...

An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides

Liu, H.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis

Nicolaou, K. C.
Hughes, Robert
Cho, Suk Young
Winssinger, Nicolas
Labischinski, Harald
Endermann, Rainer

January 2001

Based on the notion that dimerization and/or variation of amino acid 1 of vancomycin could potential...

Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis

Sinha Roy, Ranabir
Yang, Ping
Kodali, Srinivas
Xiong, Yusheng
Kim, Ronald M
Griffin, Patrick R
Onishi, H.Russell
Kohler, Joyce
Silver, Lynn L
Chapman, Kevin

November 2001

AbstractBackground: The glycopeptide antibiotic vancomycin complexes DAla-DAla termini of bacterial ...

Impact of linker modification and PEGylation of vancomycin conjugates on structure-activity relationships and pharmacokinetics

Umstätter, Florian
Werner, Julia
Zerlin, Leah
Mühlberg, Eric
Kleist, Christian
Klika, Karel D.
Hertlein, Tobias
Beijer, Barbro
Domhan, Cornelius
Zimmermann, Stefan
Ohlsen, Knut
Haberkorn, Uwe
Mier, Walter
Uhl, Philipp

January 2022

As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dram...

Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides

Umstätter, Florian
Domhan, Cornelius
Hertlein, Tobias
Ohlsen, Knut
Mühlberg, Eric
Kleist, Christian
Zimmermann, Stefan
Beijer, Barbro
Klika, Karel D.
Haberkorn, Uwe
Mier, Walter
Uhl, Philipp

January 2020

Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The inc...

Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy.

Thayer, D. A.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: a case study of vancomycin

Ritter, T. K.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Iterative chemical engineering of vancomycin leads to novel vancomycin analogs with a high in vitro therapeutic index

Mishra N.M.
Stolarzewicz I.
Cannaerts D.
Schuermans J.
Lavigne R.
Looz Y.
Landuyt B.
Schoofs L.
Schols D.
Paeshuyse J.
Hickenbotham P.
Clokie M.
Luyten W.
Briers Y.
Van Der Eycken E.V.

March 2020

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

NM Mishra (7807733)
I Stolarzewicz (7807736)
D Cannaerts (7807739)
J Schuermans (7807742)
R Lavigne (7707797)
Y Looz (7807745)
B Landuyt (7807748)
L Schoofs (7807751)
D Schols (7807754)
J Paeshuyse (7807757)
P Hickenbotham (7807760)
M Clokie (7807763)
W Luyten (7807766)
EV Van der Eycken (7807769)
Y Briers (7807772)

June 2018

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by...

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

Dongliang Guan (4731594)
Feifei Chen (283821)
Lun Xiong (4731597)
Feng Tang (136667)
Faridoon (4731588)
Yunguang Qiu (4731591)
Naixia Zhang (474251)
Likun Gong (172599)
Jian Li (41607)
Lefu Lan (345536)
Wei Huang (36889)

December 2017

Lipophilic substitution on vancomycin is an effective strategy for the development of novel vancomyc...

Natural Product Disaccharide Engineering through Tandem Glycosyltransferase Catalysis Reversibility and Neoglycosylation

Pauline Peltier-Pain (1323909)
Karen Marchillo (1376943)
Maoquan Zhou (1906096)
David R. Andes (146260)
Jon S. Thorson (534543)

October 2012

A two-step strategy for disaccharide modulation using vancomycin as a model is reported. The strateg...

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

Nakayama, Atsushi
Okano, Akinori
Feng, Yiqing
Collins, James C.
Collins, Karen C.
Walsh, Christopher T.
Boger, Dale L.

August 2014

Studies on the further development of the sequential glycosylations of the vancomycin aglycon cataly...

Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides

Losey, Heather C.
Jiang, Jiqing
Biggins, John B.
Oberthür, Markus
Ye, Xiang-Yang
Dong, Steven D.
Kahne, Daniel
Thorson, Jon S.
Walsh, Christopher T.

December 2002

AbstractAnalogs of the glycopeptide antibiotics vancomycin and teicoplanin with alterations in one o...

Substrate Inhibition of VanA by D-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner

Aart, L.T. van der
Lemmens, N.
Wamel, W.J. van
Wezel, G.P. van

August 2016

The increasing resistance of clinical pathogens against the glycopeptide antibiotic vancomycin, a la...

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C‑Terminus Substituent Effects of the Aglycon Substrate

Christopher T. Walsh
Dale L. Boger

August 2016

ABSTRACT: Studies on the further development of the sequential glycosylations of the vancomycin agly...

An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides

Liu, H.

[[sponsorship]]基因體研究中心[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...

Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis

Nicolaou, K. C.
Hughes, Robert
Cho, Suk Young
Winssinger, Nicolas
Labischinski, Harald
Endermann, Rainer

January 2001

Based on the notion that dimerization and/or variation of amino acid 1 of vancomycin could potential...

Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis

Sinha Roy, Ranabir
Yang, Ping
Kodali, Srinivas
Xiong, Yusheng
Kim, Ronald M
Griffin, Patrick R
Onishi, H.Russell
Kohler, Joyce
Silver, Lynn L
Chapman, Kevin

November 2001

AbstractBackground: The glycopeptide antibiotic vancomycin complexes DAla-DAla termini of bacterial ...

Impact of linker modification and PEGylation of vancomycin conjugates on structure-activity relationships and pharmacokinetics

Umstätter, Florian
Werner, Julia
Zerlin, Leah
Mühlberg, Eric
Kleist, Christian
Klika, Karel D.
Hertlein, Tobias
Beijer, Barbro
Domhan, Cornelius
Zimmermann, Stefan
Ohlsen, Knut
Haberkorn, Uwe
Mier, Walter
Uhl, Philipp

January 2022

As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dram...

Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides

Umstätter, Florian
Domhan, Cornelius
Hertlein, Tobias
Ohlsen, Knut
Mühlberg, Eric
Kleist, Christian
Zimmermann, Stefan
Beijer, Barbro
Klika, Karel D.
Haberkorn, Uwe
Mier, Walter
Uhl, Philipp

January 2020

Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The inc...

Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

Abstract

Extracted data

Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

Abstract

Extracted data

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