Massive stars, with a mass more than 8 Solar-masses, have a strong destructive impact on the clouds of gas and dust where they are born. My thesis examines the formation of massive stars and their impact on the surrounding gas environment. I use observations with a ground-based radiotelescope, a space-based infrared telescope, and an infrared telescope which flies in the stratosphere. To interpret these data, I use models of radiative transfer and chemical evolution of interstellar clouds.The thesis begins with high angular resolution radio observations of massive star-forming regions. To characterize the initial phases of massive star formation, we look for radio jets, a common phenomenon in low-mass star formation. The remainder of the th...