As the feature size of the transistor shrinks into nanometer scale, it becomes a grand challenge for semiconductor manufacturers to achieve good manufacturability of integrated circuits cost-effectively. In this dissertation, we aim at layout optimization algorithms from both manufacturing and design perspectives to address problems in this grand challenge. Our work covers three topics in this research area: a redundant via enhanced maze routing algorithm for yield improvement, a shuttle mask floorplanner, and optimization of post-CMP topography variation. Existing methods for redundant via insertion are all post-layout optimizations that insert redundant vias after detailed routing. In the first part of this dissertation, we propose the ...