Coronary artery disease (CAD) or ischaemic heart disease caused by atherosclerosis is the most common form of cardiovascular disease. CAD leads to acute coronary syndrome which is the clinical syndrome caused by new or growing interruption or occlusion of blood supply to a part of the heart, causing heart cells to die and myocardial infarction. Myocardial infarction destroys normal myocardium and leads directly to heart failure. This paper describes the case of male patient who in the age of 56 suffered from huge myocardial infarction, which caused important heart contractility disturbances, essential reduction in ejection fraction and provoked symptomatic heart failure. Despite fast revascularization and optimal pharmacotherapy patient rem...