International audienceThis paper proposes a new simulation framework for generat-ing realistic 3D ultrasound synthetic images that can serve for validating strain quantification algorithms. Our approach ex-tends previous work and combines a real ultrasound sequence with synthetic biomechanical and ultrasound models. It pro-vides images that fairly represent all typical ultrasound arti-facts. Ground truth motion fields are unbiased to any track-ing algorithm and model both healthy and pathological con-ditions