International audienceThe F-theorem states that in three dimensions the sphere free energy of a field theory must decrease between ultraviolet and infrared fixed points of the renormalization group flow, and it has been proven for unitary conformal field theories (CFTs).We consider here the long-range bosonic O(N)$^{3}$ model on a spherical background, at next-to-next-to-leading order of the 1/N expansion. The model displays four large-N fixed points and we test and confirm the F-theorem holds in this case. This is non-trivial as one of the couplings is imaginary, and therefore the model is non-unitary at finite N. Despite this, several tests indicating that the large-N CFTs are in fact unitary have been performed: for instance all the OPE ...