A thermostable transketolase evolved for aliphatic aldehyde acceptors.

Yi, Dong
Saravanan , Thangavelu
Devamani, Titu
Charmantray, Franck
Hecquet, Laurence
Fessner, Wolf-Dieter

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Publication date

January 2015

DOI

10.1039/C4CC08436E

Publisher

Royal Society of Chemistry (RSC)

Abstract

International audienceDirected evolution of the thermostable transketolase from Geobacillus stearothermophilus based on a pH-based colorimetric screening of smart libraries yielded several mutants with up to 16-fold higher activity for aliphatic aldehydes and high enantioselectivity (>95% ee) in the asymmetric carboligation step

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A thermostable transketolase evolved for aliphatic aldehyde acceptors.

Abstract

Extracted data

A thermostable transketolase evolved for aliphatic aldehyde acceptors.

Abstract

Extracted data

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