Investigating processes of change in regional spatial structures is a relevant issue in the identification of mono-centric, polycentric and scattered (or dispersed) urban models. The present work introduces an empirical framework grounded on complex system’s theory and aimed at a diachronic analysis of the spatial distribution and structure of built-up parcels with the aim to assess metropolitan transformations. A relational approach based on 13 metrics (parcel area and shape, nearest neighbor parcel area and shape, elevation, distances from urban centers, road infrastructures and sea coastline) was developed to investigate direction and intensity of the spatial relationship among parcel’s attributes, with the final objective to asse...