We present a novel method for the mechanical simulation of slender, elastic, spatial rods and rod structures subject to large deformation and rotation. We develop an isogeometric collocation method for the geomet-rically exact, nonlinear Cosserat rod theory. The rod centerlines are represented as spatial NURBS curvesand cross-section orientations are parameterized in terms of unit quaternions as 4-dimensional NURBS curves. Within the isogeometric framework, the strong forms of the equilibrium equations of forces and moments of the discretized Cosserat model are collocated, leading to an efficient method for higher-order discretizations. For rod structures consisting of multiple, connected rods we introduce a formulation withrigid...