International audienceThe recent detection of a very high energy (VHE) emission from Gamma-Ray Bursts (GRBs) above 100 GeV performed by the MAGIC and H.E.S.S. collaborations, has represented a significant, long-awaited result for the VHE astrophysics community. Although these results’ scientific impact has not yet been fully exploited, the possibility to detect VHE gamma-ray signals from GRBs has always been considered crucial for clarifying the poorly known physics of these objects. Furthermore, the discovery of high-energy neutrinos and gravitational waves associated with astrophysical sources have definitively opened the era of multi-messenger astrophysics, providing unique insights into the physics of extreme cosmic accelerators. In the...