Ex vivo experiments on vertebral segments with simulated lytic metastases

46ème Congrès de la Société de Biomécanique, SAINT ETIENNE, FRANCE, 25-/10/2021 - 27/10/2021Vertebral fractures of the spine are common for patients with bone metastases. This can lead to neurological deficits as well as alter the quality of life of these patients. These skeletal related events induce important health care cost due to treatments such as radiotherapy or surgery (Algra et al. 1992). To assess the fracture risk, the Spinal Instability Neoplastic Score (SINS score), ranging from 0 to 18, is based on parameters including the patient's pain, the type of metastasis, the size or the location of the metastasis. However, this score lacks of sensitivity to estimate the fracture risk for values between 7 and 12 (Fox et al. 2017). To improve prediction, biomechanical models have been developed (e.g. Groenen et al. 2018), but experimental data are still needed for validation purposes. The aim of this study was to provide biomechanical data in the case of defect affecting partly the vertebral body and one pedicle