This work consists in developing a tool for wind farm layout optimization based on Computational Fluid Dynamics (CFD) simulations of the atmospheric wind flow and inter-turbine interference. Since it is not feasible to simulate a whole wind farm using the complete geometry of the wind turbines, the need for models to represent their effects on the wind flow and the interference of one turbine on the others arises, and the most commonly used model is the Actuator Disk model and its variations. The procedure for wind turbine behavior evaluation using a CFD model was implemented in the OpenFOAM software, and this model was coupled with the Dakota optimization toolkit. A Genetic Algorithm was selected for the optimization task due to its robust...