High-mass X-ray binaries (HMXBs) consist of a black hole or neutron star accreting material from a high-mass stellar companion. Although these systems are very rare, with only about 100 having been discovered in the Milky Way Galaxy, they provide crucial insights into the evolution of high-mass stars and may have played an important role in the early Universe, heating the gas in the intergalactic medium and facilitating its reionization by the ultraviolet light produced by the first stars and galaxies. The advent of gravitational wave astronomy further motivates a more thorough understanding of HMXB populations, since HMXBs are the likely progenitors of many of the double compact binaries whose mergers will be detected by gravitational wa...