Potential strategies toward the synthesis of rifampicin were investigated. Previous studies in the laboratory of Yamamoto described the rearrangement of terminal epoxy alcohols to yield silyl protected aldol products. The stereospecific synthesis of aldol products begin with the Horner-Wadsworth-Emmons olefination of an aldehyde followed by DIBAL reduction. The allylic alcohol was subjected to a Sharpless asymmetric epoxidation reaction. The epoxyalcohol was subjected to a Payne rearrangement followed by trapping with an aryl selenide. Using our developed methodology, we were able to synthesize a library of aryl selenyl diols. The addition of Meerwein salt to aryl selenides followed by base mediated cyclization provided epoxides for the Yam...
The synthesis and cyclisation of 3-methyl-4-methylene-3-(3-diazo-3-methoxycarbonyl-2-oxopropyl)-1-cy...
The enantioselective α-deprotonation-rearrangement of trans- and cis-5-silyloxycycloheptene oxides (...
The aim of the project was to synthesise (−)-morphine utilising a tethered intramolecular imino-Diel...
In the introduction, previous synthetic approaches to morphine are reviewed; a brief outline of the ...
The preparation of 2-amino septanosides has been accomplished in two different processes. One route ...
The synthesis of morphine alkaloids involving sigmatropic rearrangements and novel ring closures of ...
The synthesis of morphine alkaloids involving sigmatropic rearrangements and novel ring closures of ...
The synthesis of a putative intramolecular Diels-Alder reaction substrate, an intermediate in a synt...
In Chapter 1, the syntheses of 2'-fluoro-N-methanocarbathymidine (2'F-NMC) and arabino 2'-fluoro-N-m...
This work consists of four consecutive parts, each dealing with syntheses of structurally diverse co...
In Chapter 1, a Diels-Alder cycloaddition strategy toward morphine utilizing highly reactive ortho-b...
text(-) Codeine, (-) morphine, and their semi-synthetic derivatives play an integral role in medicin...
The Lathyranes are a class of diterpenes characterized by a tricyclic {10.3.0.0} pentadecane ring sy...
The Cope rearrangement of gem-dimethyl-substituted divinylcyclopropanes has been used to construct f...
Chapter one describes a new approach to the synthesis of the antitumour macrolide (+)-acutiphycin, c...
The synthesis and cyclisation of 3-methyl-4-methylene-3-(3-diazo-3-methoxycarbonyl-2-oxopropyl)-1-cy...
The enantioselective α-deprotonation-rearrangement of trans- and cis-5-silyloxycycloheptene oxides (...
The aim of the project was to synthesise (−)-morphine utilising a tethered intramolecular imino-Diel...
In the introduction, previous synthetic approaches to morphine are reviewed; a brief outline of the ...
The preparation of 2-amino septanosides has been accomplished in two different processes. One route ...
The synthesis of morphine alkaloids involving sigmatropic rearrangements and novel ring closures of ...
The synthesis of morphine alkaloids involving sigmatropic rearrangements and novel ring closures of ...
The synthesis of a putative intramolecular Diels-Alder reaction substrate, an intermediate in a synt...
In Chapter 1, the syntheses of 2'-fluoro-N-methanocarbathymidine (2'F-NMC) and arabino 2'-fluoro-N-m...
This work consists of four consecutive parts, each dealing with syntheses of structurally diverse co...
In Chapter 1, a Diels-Alder cycloaddition strategy toward morphine utilizing highly reactive ortho-b...
text(-) Codeine, (-) morphine, and their semi-synthetic derivatives play an integral role in medicin...
The Lathyranes are a class of diterpenes characterized by a tricyclic {10.3.0.0} pentadecane ring sy...
The Cope rearrangement of gem-dimethyl-substituted divinylcyclopropanes has been used to construct f...
Chapter one describes a new approach to the synthesis of the antitumour macrolide (+)-acutiphycin, c...
The synthesis and cyclisation of 3-methyl-4-methylene-3-(3-diazo-3-methoxycarbonyl-2-oxopropyl)-1-cy...
The enantioselective α-deprotonation-rearrangement of trans- and cis-5-silyloxycycloheptene oxides (...
The aim of the project was to synthesise (−)-morphine utilising a tethered intramolecular imino-Diel...