Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease symptomatically characterized by progressive, fatal paralysis resulting from the degeneration of the upper and lower motor neurons of the nervous system. Although 10% of ALS is inherited in a dominant, autosomal fashion, the remaining 90% of ALS cases do not have a known genetic cause. Since the discovery of the first gene linked to familial ALS (FALS), much progress has been made towards understanding the pathological mechanisms underlying this disease. Like many neurodegenerative diseases, ALS as well as a second neurodegenerative disease, frontotemporal lobar degeneration (FTLD), are characterized by the appearance of ubiquitinated inclusions within the cytop...
Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of neurodegenera...
AbstractRecent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mec...
Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative dis...
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative dis...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerati...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerati...
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related m...
Nuclear depletion and formation of cytoplasmic inclusions of the DNA/RNA-binding protein TAR DNA-bin...
Nuclear depletion and formation of cytoplasmic inclusions of the DNA/RNA-binding protein TAR DNA-bin...
Major discoveries have been made in the recent past in the genetics, biochemistry and neuropathology...
Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of neurodegenera...
AbstractRecent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mec...
Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative dis...
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative dis...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerati...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerati...
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related m...
Nuclear depletion and formation of cytoplasmic inclusions of the DNA/RNA-binding protein TAR DNA-bin...
Nuclear depletion and formation of cytoplasmic inclusions of the DNA/RNA-binding protein TAR DNA-bin...
Major discoveries have been made in the recent past in the genetics, biochemistry and neuropathology...
Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of neurodegenera...
AbstractRecent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mec...
Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic...