Add to ORKGAmyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of mutations in the transactive response DNA-binding protein (TDP-43) and fused in sarcoma/translocated in liposarcoma (FUS/TLS) as cau-sative of ALS and FTLD, combined with the abnormal aggregation of these proteins, have initiated a shifting paradigm for the underlying pathogenesis of multiple neurodegenerative diseases. TDP-43 and FUS/TLS are both RNA/DNA-binding proteins with striking structural and functional similarities. Their association with ALS and other neurodegenerative diseases is redirecting research efforts toward understanding the role of RNA processing r...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related m...
Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerati...
Abnormal intracellular protein aggregates comprise a key characteristic in most neurodegenerative di...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of neurodegenera...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Major discoveries have been made in the recent past in the genetics, biochemistry and neuropathology...
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative dis...
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease symptomatically char...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Transactive response DNA binding protein 43. kDa (TDP-43) is a DNA and RNA binding protein involved ...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related m...
Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerati...
Abnormal intracellular protein aggregates comprise a key characteristic in most neurodegenerative di...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of neurodegenera...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Major discoveries have been made in the recent past in the genetics, biochemistry and neuropathology...
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative dis...
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease symptomatically char...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Transactive response DNA binding protein 43. kDa (TDP-43) is a DNA and RNA binding protein involved ...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related m...
Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic...