Methods for detecting the genomic signatures of natural selection have been heavily studied, and they have been successful in identifying many selective sweeps. For most of these sweeps, the favored allele remains unknown, making it difficult to distinguish carriers of the sweep from non-carriers. In an ongoing selective sweep, carriers of the favored allele are likely to contain a future most recent common ancestor. Therefore, identifying them may prove useful in predicting the evolutionary trajectory--for example, in contexts involving drug-resistant pathogen strains or cancer subclones. The main contribution of this paper is the development and analysis of a new statistic, the Haplotype Allele Frequency (HAF) score. The HAF score, assign...
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here...
Phenotypic divergences between modern human populations have developed as a result of genetic adapta...
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here...
Methods for detecting the genomic signatures of natural selection have been heavily studied, and the...
<div><p>Methods for detecting the genomic signatures of natural selection have been heavily studied,...
Positive selection causes beneficial alleles to rise to high frequency, resulting in a selective swe...
<p>(Left): Haplotype 1-HAF scores in a 50 kb window centered at known favored sites indicated by the...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
The inference of positive selection in genomes is a problem of great interest in evolutionary genomi...
Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a...
123 pagesA selective sweep happens when an adaptive allele increases in frequency and spreads throug...
The ability to detect recent natural selection in the human population would have profound implicati...
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here...
Phenotypic divergences between modern human populations have developed as a result of genetic adapta...
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here...
Methods for detecting the genomic signatures of natural selection have been heavily studied, and the...
<div><p>Methods for detecting the genomic signatures of natural selection have been heavily studied,...
Positive selection causes beneficial alleles to rise to high frequency, resulting in a selective swe...
<p>(Left): Haplotype 1-HAF scores in a 50 kb window centered at known favored sites indicated by the...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in populati...
The inference of positive selection in genomes is a problem of great interest in evolutionary genomi...
Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a...
123 pagesA selective sweep happens when an adaptive allele increases in frequency and spreads throug...
The ability to detect recent natural selection in the human population would have profound implicati...
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here...
Phenotypic divergences between modern human populations have developed as a result of genetic adapta...
There is growing interest in the use of haplotype-based methods for detecting recent selection. Here...