Predicting carriers of well-known selective sweeps.

<p>(Left): Haplotype 1-HAF scores in a 50 kb window centered at known favored sites indicated by the gene name, and the SNP identifier. (A) LCT/rs4988235, (C) TRPV/rs4987682, (E) PSCA/rs2294008, (G) ADH1B/rs1229984, and (I) EDAR/rs3827760. Points represent haplotype 1-HAF scores, red indicating a carrier of the favored allele and blue indicating a non-carrier. At the top of each panel, the number of haplotypes, <i>n</i>, is shown, with the number of carriers in parenthesis. Areas shaded in gray indicate haplotypes designated as ‘carrier’ by PreCIOSS. (Right) classification Balanced Accuracy (black) and −log₂(<i>P</i>) values (blue) as function of window size around the favored allele in (B) LCT, (D) TRPV6, (F) PSCA, (H) ADH1B, and (J) EDAR. <i>P</i>-values are for Wilcoxon rank sum tests rejecting the null hypothesis of identically distributed 1-HAF scores among carriers and non-carriers. Red circles indicate the 50 kb windows shown on the left.